We discuss two tests of the hypothesis that the first genes were assembled from exons. The hypothesis of exon shuffling in the progenote predicts that intron phases will be correlated so that exons will be an integer number of codons and predicts that the exons will be correlated with compact regions of polypeptide chain.
These predictions have been tested on ancient conserved proteins (proteins without introns in prokaryotes but with introns in eukaryotes) and hold with high statistical significance. We conclude that introns are correlated with compact features of proteins 15-, 22-, or 30-amino acid residues long, as was predicted by "The Exon Theory of Genes.”
DNA Repair provides a forum for the comprehensive coverage of cellular responses to DNA damage in living cells. The journal publishes original observations on genetic, cellular, biochemical, structural and molecular aspects of DNA repair, mutagenesis, cell cycle regulation, apoptosisand other biological responses to cells exposed to genomic insult, as well as their relationship to human diseases.
Ciclul respirator Ciclul respirator (1 inspiratie+1expiratie) are o durata de 3 secunde, ceea ce revine la 20 miscari respiratorii/ minut (normal aproximativ 12-20) = frecventa respiratorie. In efort fizic, frecventa respiratorie poate ajunge la 40-60/minut, de asemenea in conditii patologice: febra, hipertiroidism, hipercapnie, hipoxie(tahipnee).