Lupus erythematosus (LE) is an autoimmune disease of unknown cause involving the skin and/or other organs.
LE is the designation of a spectrum of diseases that are linked by distinct clinical findings and distinct pattern of polyclonal B cell immunity.
It ranges from life-threatening manifestations of systemic LE (SLE) to the limited and exclusive skin involvement in chronic cutaneous LE (CCLE).
Lupus erythematosus is a complex and highly variable disease in which a combination of genetic, immunologic and environmental factors acts in concert with the production of the disorder.
Systemic LE (SLE)
-acute cutaneous LE (ACLE): malar rash, discoid rash, photosensitivity, oral ulcers
-arthritis: nonerosive involving two or more peripheral joints
-serositis: pleuritis; pericarditis
-renal disorder: persistent proteinuria; cellular casts
-neurologic disorder: seizures; psychosis
-hematologic disorder: hemolytic anemia; leukopenia; lymphopenia; thrombocytopenia
-immunologic disorder: anti-DNA, anti-SM and antiphospholipid antibodies
-antinuclear antibody: abnormal titer of antinuclear antibodies
Cutaneous LE (CLE)
-subacute cutaneous LE (SCLE)
-chronic cutaneous LE (CCLE)