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Hematologie

Febrele hemoragice


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Clasificarea febrelor hemoragice

Transmise de căpuşe

  • §FH Crimea-Congo
  • §FH de Omsc
  • §FH de Kiasanur

 

Transmise de ţânţari

  • §Febra galbenă
  • §Febra Denghe
  • §Febra Cicungunia
  • §Febra văii Rift

 

De contact

  • §FH cu sindrom renal
  • §Febra Lassa
  • §Febra Marburg
  • §Febra Ebola
  • §Febra de Argentina
  • §Febra de Bolivia
  • §Febra de Brazilia
  • §Febra de Venesuela
  • §Four distinct viral families:
  • §Căpuşele – vectori de transmitere a febrelor hemoragice

 

Animals:

§Numerous wild and domestic animals, such as cattle, goats, sheep, and hares, serve as amplifying hosts

Filoviridae:

  • §Same clinical course as that of humans
  • §High primate mortality rate: ~ 82%

Bunyaviridae:

  • §CCHF- unapparent infection in livestock
  • §RVF- 100% abortion rate and mortality rate of > 90% in young animals and 5-60% in older animals
  • §Hantavirus – unapparent infection in rodents

Flaviviridae:

  • §Non-human primates – varying clinical signs (Yellow fever); no clinical signs (Dengue)
  • §Livestock – no symptoms (Kyasanur Forest Disease)
  • §Rodents – no symptoms

 

Humans:

Clinical signs and symptoms vary by the type of VHF

Patients usually present with the following clinical signs and symptoms:

  1. Fever ³ 38.3°C of < 3 week duration
  2. Fatigue
  3. Dizziness
  4. Muscle aches
  5. Loss of strength
  6. Exhaustion

At least two of the following:

  • Hemorrhagic or purple rash
  • Epistaxis
  • Hemoptysis
  • Blood in stools
  • Petechiae in nondependent areas

§No predisposing factors for hemorrhage and no established alternative diagnosis

 

Filoviridae:

§Most severe hemorrhagic fevers with abrupt onset and death around day 7 to 11; painful recovery

§Incubation: 4 to 10 days

§Case fatality: 23-33% (Marburg) and 53-88% (Ebola)

 

Arenaviridae:

§Incubation: 10 to 14 days

§Case fatality: 5-35%

 

Bunyaviridae:

§Incubation: 3 to 7 days (CCHF); 2 to 5 days (RVF); 7 to 21 days (Hantavirus)

§Case fatality: 30% (CCHF); 1% (RVF); 1-50% (Hantavirus)

 

Flaviviridae

§Incubation: 2 to 6 days

§Case fatality: 1-10% (Dengue); 3-5% (Kyasanur Forest virus); 0.5-3% (Omsk hemorrhagic fever); varies (Yellow fever)

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